Quinolines and derivatives
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Filtered Search Results
eMolecules N N-DISUCCINIMIDYL CARBO 100G
5000188274 N N-DISUCCINIMIDYL CARBO 100G
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Medchemexpress LLC Cinchonine | 118-10-5 | MFCD00064372 | 99.7% | 294.39 | C19H22N2O | 5g
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Cinchonine is a natural compound present in Cinchona bark with antimalarial antitumor anti-inflammatory anti platelet-aggregation and anti-obesity properties Cinchonine inhibits cells proliferation and autophagy and induces apoptosis through activation of Caspase-3 Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells[1]
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Cayman Chemical 4-HydroxyquInolIn 1g
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A quinoline alkaloid; is a core component of alkyl-4-hydroxyquinoline quorum sensing molecules; has been used as a precursor in the synthesis of compounds with antibacterial activity; has been used as a fluorescent detection reagent for iron(III) in bovine liver samples
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eMolecules EMOLECULES INC
5000471486 7-BROMOQUINOLINE 1G
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Medchemexpress LLC Hydroquinidine | 1435-55-8 | 99.97% | 5 G
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Hydroquinidine (Dihydroquinidine) is a potent ion channel blocker that exhibits strong anti-cancer activity on colon, pancreatic, and hepatocellular cancer cells. It also prolongs the QT interval and demonstrates antiarrhythmic efficacy.
- Potent ion channel blocker
- Strong anti-cancer activity on colon, pancreatic, and hepatocellular cancer cells
- Prolongs the QT interval
- Antiarrhythmic efficacy
- For research use only
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Apexbio Technology LLC LY2940680 1258861-20-9 200mg
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LY2940680 (CAS 1258861-20-9) is a selective antagonist of the Smoothened (Smo) receptor a seven-transmembrane G protein-coupled receptor involved in regulating Hedgehog (Hh) signalling LY2940680 binds primarily to the extracellular loops of Smo distinguishing it from previously described inhibitors such as SANT-1 which bind to the transmembrane domain By blocking Smo function LY2940680 suppresses downstream Hh pathway activation resulting in reduced cell proliferation observed in cell lines with Smo mutations or resistance to vismodegib Investigations of LY2940680 in basal cell carcinoma and medulloblastoma highlight its potential utility as a single-agent therapeutic targeting cancer stem cell populations
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Apexbio Technology LLC StemRegenin 1 (SR1) 1227633-49-9 200mg
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StemRegenin 1 (SR1 CAS 1227633-49-9) is a purine derivative that functions as an antagonist of the aryl hydrocarbon receptor (AhR) SR1 inhibits AhR signaling in CD34 hematopoietic progenitor cells with an IC50 value of approximately 127 nM Studies demonstrate that SR1 promotes the ex vivo expansion of CD34 cells significantly increasing both the number of CD34-expressing hematopoietic stem cells (HSCs) and their engraftment potential in immunodeficient mouse models Additionally SR1 enables differentiation and robust production of multiple dendritic cell subsets including plasmacytoid dendritic cells (pDCs) and BDCA1 /BDCA3 myeloid DCs from CD34 progenitors indicating its utility for dendritic cell research and hematopoietic stem cell biology
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Ambeed 2-CHLORO-5-NITROQUINOLINE 1X5G
NC3453475 2-CHLORO-5-NITROQUINOLINE 1X5G
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Medchemexpress LLC Cinchonine | 118-10-5 | MFCD00064372 | 99.7% | 294.39 | C19H22N2O | 25g
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Cinchonine is a natural compound present in Cinchona bark with antimalarial antitumor anti-inflammatory anti platelet-aggregation and anti-obesity properties Cinchonine inhibits cells proliferation and autophagy and induces apoptosis through activation of Caspase-3 Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells[1]
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eMolecules LEUPEPTIN HEMISULFATE 25MG
5000190006 LEUPEPTIN HEMISULFATE 25MG
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Medchemexpress LLC Amino-PEG6-amine | 76927-70-3 | ≥ 97.0% | 324.41 | 100 MG
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Amino-PEG6-amine is a PEG-based (6 units) PROTAC linker. It can be used in the synthesis of PROTACs, which are molecules that exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. PROTACs achieve this by containing two different ligands connected by a linker: one ligand binds to an E3 ubiquitin ligase, and the other binds to the target protein.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the ubiquitin-proteasome system
- Selectively degrades target proteins
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eMolecules EMOLECULES INC
5000473910 2-METHOXYPYRIDINE-4-CARBA 25MG
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Medchemexpress LLC 3-Thiazolidinepropanoic acid, 5-(5-chloro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)-4-oxo-2-thioxo- | 1426138-42-2 | 98.0% | 368.82 g/mol | C14H9ClN2O4S2 | 200 MG
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FX1 is a small-molecule inhibitor of the transcriptional repressor BCL6, used as a research tool to probe BCL6-mediated transcriptional regulation and apoptosis. It is supplied as a solid and is suitable for biochemical and cellular studies.
- Inhibits BCL6 with IC50 ≈ 35 μM
- High purity (98.0%) suitable for research applications
- Solid form, pink to red color
- Molecular formula C14H9ClN2O4S2; molecular weight 368.82 g/mol
- Available in multiple pack sizes including 200 MG
- Powder storage: -20°C (3 years) or 4°C (2 years)
- Intended for biochemical assays and cellular pathway studies
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Medchemexpress LLC Danofloxacin mesylate | 119478-55-6 | MFCD00673687 | 99.9% | 100 MG
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Danofloxacin mesylate (CP 76136-27) is a fluoroquinolone used as a veterinary drug. It exhibits broad-spectrum bactericidal activity primarily by inhibiting bacterial DNA gyrase and also functions as a substrate for ATP-dependent efflux transporters such as P-gp and MRP2.
- Used as a veterinary drug
- Broad-spectrum bactericidal activity
- Inhibits bacterial DNA gyrase
- Substrate for ATP-dependent efflux transporters (P-gp and MRP2)
- Targets P-glycoprotein and bacterial components
- Involves membrane transporter/ion channel and anti-infection mechanisms
- Effective against bovine bacterial respiratory pathogens
- Demonstrates asymmetric transport across Caco-2 cells
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Apexbio Technology LLC Lonafarnib 193275-84-2 200mg
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Lonafarnib (CAS 193275-84-2) also known as SCH66336 or Sarasar is a tricyclic orally bioavailable inhibitor of farnesyltransferase (FTase) functioning without peptide or sulfhydryl groups FTase mediates post-translational farnesylation of Ras proteins a modification required for their membrane localization and activation of downstream signaling pathways involved in cellular growth proliferation and survival By inhibiting this enzymatic activity Lonafarnib disrupts Ras translocation to the plasma membrane limiting Ras-mediated signaling Currently Lonafarnib is widely evaluated in preclinical and clinical investigations particularly in oncology contexts
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